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DOR BioPharma, Inc. (OTCBB: DORB) (DOR or the Company) announced that facts from its pivotal Phase 3 and supportive Phase 2 clinical trial using orBec(r) (oral beclomethasone dipropionate, or BDP) to pleasure gastrointestinal Graft-versus-Host bad Health (GI GVHD) enjoy be pre-published this afternoon delimited by the online edition of Blood, the peer-reviewed Journal of the American Society of Hematology, in situation of a First Edition broadsheet, near long-term continuation analyses from these two randomized, double-blinded, placebo-controlled trials not in earlier times made laypeople.  Lead novelist of the research, okay “A Randomized, Placebo-controlled Trial of Oral Beclomethasone Dipropionate as a Prednisone-Sparing Therapy all for Gastrointestinal Graft-versus-Host Disease,” be David M. Hockenbery, M.D., Member of the Clinical Research Division, Fred Hutchinson Cancer Research Center and Professor of Medicine, University of Washington School of Medicine, both positioned in Seattle, Washington.  The full up article is going spare online at The Blood paper cover wide-ranging grades from two study: Â  DOR’s 129-patient pivotal Phase 3, randomized, double-blinded, placebo-controlled multi-center clinical research of orBec(r) conduct at 16 central clean marrow/stem cell transplant centers in the U.S. and France; and survival data from its 60-patient Phase 2, randomized, double-blinded, placebo-controlled clinical trial conducted at the Fred Hutchinson Cancer Research Center.

Comprehensive Long-Term Mortality Results Among the current data grass today, orBec(r) show importunate survival gain when equate to placebo one year after randomization in the pivotal Phase 3 trial.  Overall, 18 patients (29%) in the orBec(r) league and 28 patients (42%) in the placebo group pass away in the house one year of randomization (46% concession in mortality, menace ratio 0.54, 95% CI: 0.30, 0.99, p=0.04, stratified log-rank test).  Results from the Phase 2 trial also demonstrated enhanced long-term survival benefit with orBec(r) versus placebo.  In that study, at one year after randomization, 6 of 31 patients (19%) in the orBec(r) group while 9 of 29 patients (31%) in the placebo group have died (45% reduction in mortality, p=0.26).  Pooling the survival data from both trials demonstrated that the survival benefit of orBec(r) analysis be never-ending drawn out after orBec(r) was discontinue and lengthy okay gone 3 years after the transplant.  As of September 25, 2005, median maintenance of patients in the two trials was 3.5 years (placebo patients) and 3.6 years (orBec(r) patients), with a inventory of 10.6 months to 11.1 years.  The speculate of mortality was 37% degrade for patients randomized to orBec(r) compared with placebo (hazard ratio 0.63, p=0.03, stratified log-rank test).

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